Families at risk of colorectal cancer: who are they?

Evaluation of MLH1 and MSH2 Gene Mutations in a Subset of Iranian Families with Hereditary Nonpolyposis Colorectal Cancer (HNPCC)

کاربرد مدل ریسک رقابتی در شناسایی عوامل موثر بر زمان بقای بیماران مبتلا به سرطان کولورکتال

Background and Objective: Colorectal cancer is the most common cancer of digestive system in Iran.The incidence of this cancer has increased in recent years.The aim of this study was to evaluate the survival rate and to define the prognostic factors in Iranian colorectal cancer patients using competing risk model. Materials and Methods: Data recorded from 1060 patients with colorectal cancer...

A familial gastrointestinal cancer clinic: organization, aims and activities, 2004-2007.

BACKGROUND Dedicated, organ-specific screening clinics have been shown to significantly reduce cancer morbidity and mortality. OBJECTIVES To establish a dedicated clinic for Clalit Health Service patients at high risk for hereditary gastrointestinal cancer and to provide them with clinical and genetic counseling, diagnostic screening and follow-up. RESULTS During the 3 years of the clinic's...

ارتباط پلی مورفیسم C>T p757lدر ژن Exo1 و ریسک ابتلا به سرطان کلورکتال غیر ارثی در یک جمعیت از ایران

Introduction & Objective: One candidate gene for colorectal cancer susceptibility is exonuclease1 (EXO1) .It is a member of RAD2 nuclease family. It plays a main role in mismatch repair. EXO1 acts also in DNA replication and recombination. Single nucleotide polymorphisms (SNPs) are shown to be related with cancer incidence. The aim of the present study was to examine the association between P...

بررسی بقای بیماران مبتلا به سرطان کولورکتال با استفاده از مدل ریسک رقابتی پارامتری

Background and Objective: Colorectal cancer is the most common cancer of digestive system in Iran. The incidence of this cancer has increased in recent years.The aim of this study was to evaluate the survival rate and to define the prognostic factors in Iranian colorectal cancer patients using competing risk model. Materials and Methods: Data were recorded from 1060 patients with colorec...

Improving the ascertainment of families at high risk of colorectal cancer: a prospective GP register study.

BACKGROUND Screening for colorectal cancer is effective in family members with a high risk of this condition, owing to single gene mutations. However, it is not known which is the most effective method of ascertaining these families at high risk. AIMS To investigate whether a case-finding approach using computerised general practitioner (GP) registers would improve the ascertainment of famili...